Endocrine Abstracts

Despite significant progress in understanding the regulation of phosphate (Pi) homeostasis over the past 20 years, the mechanisms underlying the very early step leading to the regulating cascade involving multiple hormones (PTH, vitamin D, FGF23) and organs (kidney, intestine, bone, parathyroid glands) are not deciphered. Progress in this area is based on on the ability to identify and characterise the Pi-sensing mechanism in mammals that allow cells or organisms to detect cha...